PGN-9856

SKU: orb1740966

Description

PGN-9856 is a selective, high-affinity EP2 receptor agonist with demonstrated anti-inflammatory and intraocular pressure-lowering effects. It is a valuable research tool for studying glaucoma and EP2-mediated pathways in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 863704-91-0
• MW: 383.35
• Purity: 99.27% (May vary between batches)
• Formula: C₂₁H₁₅F₂NO₄
• SMILES: O=C(O)COC1=CC=CC(=C1)NC(=O)C=2C=C(C=CC2F)C3=CC=CC(F)=C3
• Target: Prostaglandin Receptor
• Solubility: DMSO:100 mg/mL (260.86 mM)

Bioactivity

• Target IC50:
  EP2:≥ 8.5 (pEC50)|EP2:≥ 8.3 (pKi)
• In Vivo:
  PGN-9856 has uterine contraction inhibition, anti-inflammatory and long-term IOP lowering properties.
• In Vitro:
  PGN-9856 is a selective, high-affinity (pKi ≥ 8.3) human recombinant EP2 receptor ligand.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PGN-9856, PGN 9856, PGN9856

Compound Identifiers

PubChem CID

59654860