PFM046

SKU: orb2945834

Description

PFM046 is a potent dual LXRα/β antagonist (IC50: 2.04 μM and 1.58 μM, respectively). It modulates lipid metabolism genes by downregulating SCD1 and FASN while upregulating ABCA1, and has shown antitumor efficacy in mouse models, supporting its use in oncology and metabolic disease research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 3053859-57-4
• MW: 422.643
• Formula: C₂₉H₄₂O₂
• SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(CC[C@@]2([C@@H]([C@H](CC5=CC=CC=C5)O)C)[H])[H]
• Target: Stearoyl-CoA Desaturase (SCD),Fatty Acid Synthase,Liver X Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677439