PFKFB4-IN-1

SKU: orb3173787

Description

PFKFB4-IN-1 is a potent and selective ATP-competitive inhibitor of PFKFB4 (IC50 = 4.50 μM) that reduces intracellular PFKFB4 protein levels. It exhibits over 12-fold selectivity for PFKFB1/4 and PFKFB3/4 isoforms. PFKFB4-IN-1 inhibits cancer cell proliferation, induces apoptosis, and suppresses cell migration. It also hinders tumor growth in MDA-MB-231 xenograft mouse models. PFKFB4-IN-1 is applicable for studies related to breast cancer, lung cancer, and liver cancer.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2664831-55-2
• MW: 318.21
• Formula: C₁₁H₆N₆O₆
• SMILES: O=N(=O)C=1OC(C=NNC2=CC=C(C3=NON=C32)N(=O)=O)=CC1
• Target: Apoptosis,Caspase,Phosphatase,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,Phosphatase,PARP