PFK-015

SKU: orb1305460

Description

PFK-015

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 4382-63-2
• MW: 260.29
• Purity: 98.94%
• Formula: C₁₇H₁₂N₂O
• SMILES: O=C(\C=C\c1ccc2ccccc2n1)c1ccncc1
• Target: Glucokinase,Autophagy
• Solubility: DMSO:3 mg/mL (11.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.84 mM)

Bioactivity

• Target IC50:
  PFKFB3:110 nM|PFKFB3:20 nM
• In Vivo:
  PFK-015 effectively reduces levels of F26BP, glucose uptake, and intracellular adenosine triphosphate (ATP) in Jurkat T-cell leukemia cells and H522 lung adenocarcinoma cells. Additionally, PFK-015 exhibits significant inhibitory effects on the growth of a variety of cancer cells.
• In Vitro:
  PFK-015 (25 mg/kg, i.p.) inhibits the growth, metastatic spread, and glucose metabolism of LLC tumors in syngeneic mice. In three distinct athymic mouse models of xenografted human cancers, the anticancer efficacy of PFK-015 is comparable to that of established chemotherapy drugs. PFK-015 exhibits favorable pharmacokinetic properties in vivo.
• Cell Research:
  Viability is determined using trypan blue exclusion. Cells were incubated in 20% trypan blue for 5 minutes. Cells excluding trypan blue are counted using a standard hemocytometer to determine the total number of viable cells. Experiments are conducted in triplicate. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, esophageal squamous cell carcinoma (ESCC), lung cancer, inhibit, 3PO, cancers, Autophagy, colon cancer, stomach cancer, PFKFB3, PFK015, PFK-015, PFK15, PFK-15, PFK 15, PFK 015

Compound Identifiers

PubChem CID

25142799