Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

PFI-2

SKU: orb1705930

Description

PFI-2

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1627676-59-8
MW499.52
Purity99.38% (May vary between batches)
FormulaC23H25F4N3O3S
SMILESFC1=C2C(=CC(S(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(=O)N4CCCC4)(=O)=O)=C1)CCNC2
TargetHistone Methyltransferase
SolubilityDMSO:100 mg/mL (200.19 mM);Ethanol:66 mg/mL (132.13 mM)

Bioactivity

Target IC50
SETD7:2 nM
In Vivo
In the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

(R)-PFI-2, chronic kidney disease, Histone Methyltransferase, HistoneMethyltransferase, Inhibitor, inhibit, inflammation, macrophage, renal fibrosis, SETD7, SET domain containing lysine methyltransferase 7 (SETD7), PFI2, PFI-2, PFI 2

Similar Products

  • (S)-PFI-2 HCl [orb315387]

    >97%

    1627607-88-8

    535.98

    C23H25F4N3O3S.HCl

    5 mg
  • PFI-2 HCl (R-) [orb1302737]

    >98%

    1627607-87-7

    535.98

    C23H25F4N3O3S HCl

    5 mg, 25 mg
  • SETD7-IN-1 [orb1943589]

    5 mg, 50 mg
  • PFI-2 [orb1226028]

    >98% (HPLC)

    1627676-59-8

    499.5215

    C23H25F4N3O3S

    10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 5 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 80.00
2 mg
$ 100.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 300.00
50 mg
$ 480.00
100 mg
$ 740.00
200 mg
$ 1,010.00
DispatchUsually dispatched within 5-10 working days
Bulk Enquiry