PF9366

SKU: orb1221052

Description

PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor (IC50: 420 nM; Kd: 170 nM).

Key Properties

• CAS Number: 72882-78-1
• MW: 350.84
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₉ClN₄
• SMILES: CN(C)CCc1nnc2cc(-c3ccccc3)c3cc(Cl)ccc3n12
• Target: Mat2A
• Solubility: DMSO: 20 mg/mL (57 mM)

Bioactivity

• In Vitro:
  PF-9366 is a Mat2A inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. PF-9366 displays no substantial off-target activity in GPCRs, neurotransporters, phosphodiesterases, and ion channels. PF-9366 has inhibitory activity against Mat2A in cancer cells. PF-9366 inhibits cellular S-Adenosyl-L-methionine (SAM) production with an IC50 of 1.2 μM in H520 lung carcinoma cells. PF-9366 is more potent in Huh-7 cells against SAM synthesis, with an IC50 of 255 nM, and also suppresses the proliferation of cells with an IC50 of 10 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF 9366 | PF-9366

Quick Database Links

Gene Symbol

Mat2A