PF07104091

SKU: orb1297928

Description

PF07104091 is a selective CDK2 inhibitor that induces cell cycle arrest and apoptosis, thereby suppressing tumor cell proliferation. It is a valuable research tool for studying cell cycle dynamics and oncology, with applications in both in vitro and in vivo cancer models.

Research Area

Cell Biology

Key Properties

• CAS Number: 2460249-19-6
• MW: 404.46
• Purity: 99.59% (May vary between batches)
• Formula: C₁₉H₂₈N₆O₄
• SMILES: N(C(=O)C1=CC(COC)=NN1C)C2=CC(=NN2)[C@@H]3C[C@H](OC(NC(C)C)=O)CC3
• Target: CDK
• Solubility: DMSO:55 mg/mL (135.98 mM)

Bioactivity

• In Vitro:
  PF-07104091 hydrate (Example 13) inhibits CDK1/cyclin A2, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9, with Kis of 110, 238, 465 and 117 nM. METHODS: We explored whether CDK2 activity could be completely abolished by pharmacological treatment with supraphysiological doses of PF3600 (10 μM) or PF4091 (20 μM). RESULTS We observed an immediate collapse of the DHB reporter signal below the mitotic nadir, without a hump.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF07104091, PF-07104091, PF 07104091, CDK2

Compound Identifiers

PubChem CID

154616422