PF00835231(SARS-CoV-2 inhibitor 5h)

SKU: orb746324

Description

PF00835231(SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 µM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 µM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.

Key Properties

• CAS Number: 870153-29-0
• MW: 575.68
• Formula: C₃₀H₃₃N₅O₅S
• SMILES: COc1c2c([nH]c(c2)C(N[C@H](C(N[C@H](C(c2sc3c(cccc3)n2)=O)C[C@H]2C(=O)NCC2)=O)CC(C)C)=O)ccc1

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only