PF-AKT400

SKU: orb1301735

Description

PF-AKT400 is a potent, ATP-competitive small molecule inhibitor with broad selectivity for the Akt kinase family. It is widely used in preclinical research to investigate the PI3K/Akt signaling pathway in cancer biology, supporting both in vitro cellular assays and in vivo tumor model studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1004990-28-6
• MW: 400.43
• Purity: 99.82% (May vary between batches)
• Formula: C₂₀H₂₂F₂N₆O
• SMILES: CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12
• Target: Akt
• Solubility: DMSO:90 mg/mL (224.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM)

Bioactivity

• Target IC50:
  PKBα:0.5 nM|PKA:450 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, AKT protein kinase inhibitor, inhibit, Inhibitor, Protein kinase B, PF AKT400, PF-AKT 400, PFAKT400, PF-AKT400, PF-AKT-400, PKB

Compound Identifiers

PubChem CID

25061501