PF-6274484

SKU: orb1305952

Description

PF-6274484 is a potent, irreversible covalent EGFR kinase inhibitor with a Ki of 0.14 nM. It effectively blocks autophosphorylation of wild-type EGFR and the EGFRL858R/T790M mutant in cellular assays, with IC50 values of 5.8 nM and 6.6 nM, respectively. This inhibitor is a valuable tool for in vitro research in non-small cell lung cancer and resistance mechanism studies.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1035638-91-5
• MW: 372.78
• Purity: 99.12%
• Formula: C₁₈H₁₄ClFN₄O₂
• SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
• Target: EGFR
• Solubility: DMSO:65 mg/mL (174.37 mM)

Bioactivity

• Target IC50:
  EGFR (WT):0.18 nM (Ki)|EGFR:0.14 nM(Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cysteine, autophosphorylation, kinase, inhibit, HER1, Inhibitor, Epidermal growth factor receptor, ErbB-1, EGFR, signaling, oxidation, PF-6274484, PF6274484, PF 6274484, protein

Compound Identifiers

PubChem CID

74766099