PF-562271 hydrochloride

SKU: orb1306208

Description

PF-562271 HCl is a potent, selective, and reversible ATP-competitive inhibitor of focal adhesion kinase (FAK) with an IC50 of 1.5 nM. It exhibits >100-fold selectivity over most kinases and has been utilized in both in vitro and in vivo studies to investigate FAK's role in cancer cell migration, invasion, and tumor progression.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 939791-41-0
• MW: 543.95
• Purity: 98.52% (May vary between batches)
• Formula: C₂₁H₂₀F₃N₇O₃S HCl
• SMILES: Cl.CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
• Target: PYK2,CDK,FAK
• Solubility: DMSO:91 mg/mL (167.29 mM)

Bioactivity

• Target IC50:
  FAK:1.5 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CDK3, CDK2, CDK1, CDK7, Breast, Cancer, Antitumor, inhibit, Inhibitor, Focal adhesion kinase, Ewing, FAK, PYK2, Pyk2, PF562271 hydrochloride, PF562271 Hydrochloride, PF-562271 Hydrochloride, PF-562271 HCl, PF562271, PF-562271, PF 562271 Hydrochloride, PF 562271 hydrochloride, PF 562271, Sarcoma, PTK2 protein tyrosine kinase 2, PTK2, Proline-rich tyrosine kinase 2, VS-6062(hydrochloride)

Compound Identifiers

PubChem CID

16222312