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Catalog Number | orb1306208 |
---|---|
Category | Small Molecules |
Description | PF-562271 hydrochloride |
CAS Number | 939791-41-0 |
Purity | 98.52% |
MW | 543.95 |
SMILES | Cl.CN(c1ncccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O |
Formula | C21H20F3N7O3S HCl |
Biological Activity | PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and > 100-fold selectivity against other protein kinases, except for some CDKs. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |