PF-4942847

SKU: orb2814791

Description

PF-4942847 is a novel, orally bioavailable Hsp90 inhibitor under investigation for triple-negative breast cancer (TNBC) due to its synergistic disruption of multiple oncogenic pathways. Its mechanism, demonstrated in vitro and in vivo, includes inducing AKT degradation in peripheral blood lymphocytes, a potential pharmacodynamic biomarker for clinical trials.

Key Properties

• CAS Number: 1046859-34-0
• MW: 516.3
• Formula: C₂₀H₁₈Cl₂F₃N₇O₂
• SMILES: O=C(NCC(F)(F)F)N1CC=2N=C(N=C(C=3C(Cl)=CC(Cl)=CC3OCCN4N=CC=C4)C2C1)N

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

53236589