PF-4708671

SKU: orb1306778

Description

PF-4708671 is a potent and cell-permeable small molecule inhibitor targeting the S6K1 isoform of p70 ribosomal S6 kinase, with a Ki50 of 20 nM and an IC50 of 160 nM in biochemical assays. It is widely used in research to investigate mTOR/S6K signaling pathways in cellular models of metabolism, growth, and cancer, and has been employed in both in vitro and in vivo experimental settings.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1255517-76-0
• MW: 390.41
• Purity: 99.98%
• Formula: C₁₉H₂₁F₃N₆
• SMILES: CCc1cncnc1N1CCN(Cc2nc3cc(ccc3[nH]2)C(F)(F)F)CC1
• Target: Autophagy,S6 Kinase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM);DMSO:19.5 mg/mL (49.95 mM);Ethanol:19.5 mg/mL (49.95 mM)

Bioactivity

• Target IC50:
  p70 S6K1:160 nM|S6K1:20 nM (Ki)|S6K2:65 μM
• In Vivo:
  PF-4708671 inhibits the phosphorylation of S6 protein mediated by S6K1 in response to IGF-1 (Insulin-like Growth Factor 1) and can also induce the phosphorylation of the T-loop and hydrophobic motif of S6K1 through mTORC1 (mTOR complex 1).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, p70 S6K, Autophagy, PF4708671, PF-4708671, PF 4708671, S6 Kinase, S6K, S6Kinase, Ribosomal S6 Kinase (RSK)

Compound Identifiers

PubChem CID

51371303