PF-431396

SKU: orb1305715

Description

PF-431396 is a potent small molecule inhibitor targeting both PYK2 and FAK kinases, with IC50 values of 11 nM and 2 nM, respectively. It is a valuable research tool for studying focal adhesion dynamics and has been utilized in both in vitro and in vivo models to investigate cancer cell migration, invasion, and metastasis.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 717906-29-1
• MW: 506.5
• Purity: 99.82% (May vary between batches)
• Formula: C₂₂H₂₁F₃N₆O₃S
• SMILES: CN(c1ccccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O
• Target: PYK2,FAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM);DMSO:25.3 mg/mL (49.95 mM)

Bioactivity

• Target IC50:
  PYK2:11 nM|FAK:2 nM
• In Vitro:
  PF-431396 consistently inhibits protein tyrosine kinase phosphorylation under both calcium deficiency and the presence of Ca/W-7. It also blocks tyrosine phosphorylation of Pyk2 and FAK induced by anti-Ig- and aggregated LFA-1 in A20 cells, thereby inhibiting B cell proliferation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proline-rich tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2, PF431396, PF-431396, PF 431396, Pyk2, PYK2, inhibit, Inhibitor, Focal adhesion kinase, FAK

Compound Identifiers

PubChem CID

11598628