PF-3758309 hydrochloride

SKU: orb1303039

Description

PF-3758309 hydrochloride is an orally bioavailable small-molecule inhibitor targeting p21-activated kinase 4 (PAK4), which is frequently overexpressed in cancers. Its inhibition of PAK4 activity disrupts cancer cell proliferation and survival, demonstrating antitumor effects in both cellular assays and in vivo xenograft models across various cancer types.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1279034-84-2
• MW: 527.08
• Purity: >99.99% (May vary between batches)
• Formula: C₂₅H₃₁ClN₈OS
• SMILES: Cl.CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1
• Target: PAK,Apoptosis
• Solubility: DMSO:45 mg/mL (85.38 mM)

Bioactivity

• Target IC50:
  PAK5:18.1 nM (Ki)|PAK3:99 nM (IC50)|PAK4:18.7 nM (Ki)|PAK4:2.7 nM (Kd)|PAK1:13.7 nM (Ki)|PAK2:190 nM (IC50)|PAK6:17.1 nM (Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATP-competitive, Apoptosis, oncogenic, PAK, PAK3, PAK1, PAK4, PAK5, PAK6, inhibit, Inhibitor, growth, signaling, PF 03758309 Hydrochloride, PF 03758309, PF 3758309, PF 3758309 Hydrochloride, PF 3758309 hydrochloride, PF3758309, PF-3758309, PF3758309 hydrochloride, PF3758309 Hydrochloride, PF-3758309 Hydrochloride, PF-03758309, PF03758309 Hydrochloride, PF-03758309 hydrochloride, PF-03758309 Hydrochloride, PF03758309, p21 activated kinases, proliferation, survival, tumor

Compound Identifiers

PubChem CID

76972060