PF-249

SKU: orb1305452

Description

PF-249 (PF-06685249) is a potent and β1-selective AMPK activator, demonstrating an EC50 of 12 nM for the α1β1γ1 isoform. This small molecule is a valuable research tool for investigating metabolic diseases, including studies on diabetic nephropathy in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1467059-70-6
• MW: 345.78
• Purity: 97.01% (May vary between batches)
• Formula: C₁₇H₁₆ClN₃O₃
• SMILES: COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N(C)C
• Target: AMPK
• Solubility: DMSO:90 mg/mL (260.28 mM)

Bioactivity

• Target IC50:
  AMPK α1β1γ1:12 nM (EC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK α1β1γ1, PF 249, PF 06685249, PF06685249, PF-06685249, PF249, PF-249

Compound Identifiers

PubChem CID

71767991