PF-07245303

SKU: orb3210604

Description

PF-07245303 is an ITK/TRK inhibitor that reduces the production of inflammatory factors such as IL-4 and IFNγ, and inhibits the phosphorylation of PLCγ1. It suppresses basophil activation induced by nerve growth factor and inhibits TRKA phosphorylation. Additionally, PF-07245303 decreases oxazolone-induced ear swelling in mouse ear tissue. This compound has applications in research on atopic dermatitis.

Key Properties

• CAS Number: 2655556-75-3
• MW: 448.56
• Formula: C₂₅H₃₂N₆O₂
• SMILES: C[C@@]12CC3=C(C(=NN3)C=4NC=5C(N4)=CC(C)=C(N(C([C@H](C)N6CCOCC6)=O)C)C5)C[C@@]1(C2)[H]
• Target: Interleukin,IFNAR,Tyrosine Kinases,Trk receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,IFNAR,Tyrosine Kinases,Trk receptor