PF-06855800

SKU: orb2655803

Description

PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM; demonstrates antiproliferative activity in Z-138 cancer cells with IC50 of 1 nM, also shows anti-tumor activity in Z-138 mice xenograft models.

Key Properties

• CAS Number: 1989620-04-3
• MW: 392.811
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈ClFN₂O₄
• SMILES: NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H]([C@@H](C4=CC=C(Cl)C(F)=C4)O)O3)O)O)C=C2)=NC=N1
• Target: HMTase
• Solubility: In Vitro: DMSO : 125 mg/mL (316.63 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF06855800

Quick Database Links

Gene Symbol

HMTase