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PF-06459988

SKU: orb1307899

Description

PF-06459988 is a potent, selective, and irreversible oral inhibitor targeting EGFR mutants, particularly those with T790M resistance mutations, while sparing wild-type EGFR. It serves as a research tool for investigating non-small cell lung cancer (NSCLC) in both cellular and animal models of EGFR-driven tumorigenesis.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1428774-45-1
MW431.88
Purity98.00%
FormulaC19H22ClN7O3
SMILESCO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C
TargetEGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

PF-06459988 (orb1307899)

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1 mg
$ 190.00
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