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PF-06454589

SKU: orb1299557

Description

PF-06454589 is a highly effective small molecule LRRK2 kinase inhibitor. It is a valuable research tool for studying Parkinson's disease mechanisms in both cellular (in vitro) and animal (in vivo) models, aiding in the investigation of LRRK2's role in neurobiology.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1527473-30-8
MW284.32
Purity99.06%
FormulaC14H16N6O
SMILESCn1cc(cn1)-c1c[nH]c2ncnc(N3CCOCC3)c12
TargetLRRK2
SolubilityDMSO:9 mg/mL (31.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.52 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF 06454589, PF06454589, PF-06454589, Inhibitor, Leucine-rich repeat kinase 2, G2019S LRRK2, inhibit, LRRK2, parkinson's disease
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

PF-06454589 (orb1299557)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 120.00
25 mg
$ 180.00
50 mg
$ 250.00
100 mg
$ 370.00
200 mg
$ 510.00
DispatchUsually dispatched within 3-5 working days
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