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PF-06260933

SKU: orb1225883

Description

PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM; demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM); inhibits LPS-induced plasma TNFα levels in mouse model.

Images & Validation

Key Properties

CAS Number1811510-56-1
MW296.754
Purity>98% (HPLC)
FormulaC16H13ClN4
SMILESC1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
TargetMAP4K
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PF 6260933 | PF6260933

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Protocol Information

PF-06260933 (orb1225883)

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Available Sizes

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200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 170.00
10 mg
$ 240.00
25 mg
$ 470.00
50 mg
$ 730.00
100 mg
$ 1,040.00