PF-05175157

SKU: orb1685517

Description

PF-05175157

Research Area

Metabolism Research

Key Properties

• CAS Number: 1301214-47-0
• MW: 405.49
• Purity: 99.92%
• Formula: C₂₃H₂₇N₅O₂
• SMILES: CC(C)n1ncc2CC3(CCN(CC3)C(=O)c3ccc4nc(C)[nH]c4c3)CC(=O)c12
• Target: Acetyl-CoA Carboxylase
• Solubility: DMSO:140 mg/mL (345.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.47 mM)

Bioactivity

• Target IC50:
  ACC1 (rat):23.5 nM |ACC2 (human):33.0 nM |ACC2 (rat):50.4 nM|ACC1 (human):27.0 nM
• In Vivo:
  PF-05175157 induced a reduction of the viral load in serum and kidney in WNV-infected mice, unveiling its therapeutic potential for the treatment of chronic kidney disease associated with persistent WNV infection.
• Animal Research:
  Pharmacokinetics was analyzed after a single oral dose of the compounds (in a 0.5% methyl cellulose suspension) administered to fasted male mice. A dose of 15 mg/kg for PF-05175157 or 100 mg/kg in the case of PF-05206574 and PF-06256254 was analyzed. Antiviral activity in vivo was determined using eight-week-old Swiss albino CD-1 female mice. Animals were treated with PF-05175157 (20 mg/kg) suspended in 1% carboxymethylcellulose by oral gavage twice a day from 1 d before infection with WNV (1 × 10^4 PFU/mouse intraperitoneally) and up to 7 days post-infection. Control mice were treated in parallel with drug vehicle (carboxymethylcellulose). For experiments evaluating the effect of genetic deletion of ACC2 gene on WNV infection, a breeding colony of C57BL/6 ACC2-/- mice was established from two heterozygous Acabtm1Dejs females . Age- and sex-matched eight-week-old ACC2-/- and control wild type (WT) mice were challenged with WNV (1 × 10^4 PFU/animal.). Animals were monitored daily and received water and food ad libitum.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AcetylCoA Carboxylase, Acetyl-CoA Carboxylase, AcetylCoACarboxylase, ACC, ACC, Acetyl Coenzyme A Carboxylase, Inhibitor, inhibit, PF 05175157, PF05175157, PF-05175157

Compound Identifiers

PubChem CID

52934180