PF 05089771

SKU: orb1299763

Description

PF 05089771 is a potent and selective Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 11 nM) that binds to the voltage-sensor domain IV. Its blocking action exhibits a slow, depolarization- and concentration-dependent onset. This compound is a valuable research tool for investigating pain pathways in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1235403-62-9
• MW: 500.35
• Purity: 99.57%
• Formula: C₁₈H₁₂Cl₂FN₅O₃S₂
• SMILES: Nc1n[nH]cc1-c1cc(Cl)ccc1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
• Target: Sodium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM);DMSO:30 mg/mL (59.96 mM)

Bioactivity

• Target IC50:
  CynNav1.7:12 nM (IC50)|Nav1.7 (rat):171 nM (IC50)|Nav1.7 (dog):13 nM (IC50)|Nav1.7 (mouse):8 nM (IC50)|Nav1.7 (human):11 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diabetic, neuropathy, Nav1.7 channel, Na channels, Na+ channels, pain, inhibit, Inhibitor, PF 05089771, PF05089771, PF-05089771, Sodium Channel, SodiumChannel, TTX-R, tetrodotoxin

Compound Identifiers

PubChem CID

46840946