PF-04979064

SKU: orb1299901

Description

PF-04979064 is a potent dual kinase inhibitor targeting both PI3K and mTOR with high selectivity (Ki values of 0.13 nM and 1.42 nM, respectively). This compound is a valuable research tool for studying PI3K/mTOR signaling pathways in oncology and metabolic disease research, applicable in both cellular and in vivo models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1220699-06-8
• MW: 446.5
• Purity: 99.98%
• Formula: C₂₄H₂₆N₆O₃
• SMILES: C[C@H](O)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O
• Target: PI3K,mTOR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.24 mM);DMSO:4.47 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  PI3Kα:0.13 nM (Ki) |mTOR:1.42 nM (Ki)|PI3Kγ:0.111 nM (Ki) |PI3Kδ:0.122 nM (Ki)
• In Vivo:
  PF-04979064 was tested against human class I PI3K isoforms α, γ, and δ, with PI3Kα Ki of 0.130 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.PF-04979064 was progressed to rat in vivo PK studies and exhibited robust PK profile: Vdss = 5.23 L/kg, Cl = 19.3 mL/min/kg, T1/2 = 1.85 h, and F % = 61%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mammalian target of Rapamycin, mTOR, Inhibitor, inhibit, Phosphoinositide 3-kinase, PI3K, PF04979064, PF-04979064, PF 04979064

Compound Identifiers

PubChem CID

46866705