PF-04957325

SKU: orb1708890

Description

PF-04957325 is a potent, selective PDE8 inhibitor with IC50 values of 0.7 nM for PDE8A and 0.3 nM for PDE8B. It serves as a valuable research tool for investigating PDE8 biology in models of autoimmune diseases like encephalomyelitis, applicable in both in vitro and in vivo studies.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1305115-80-3
• MW: 400.38
• Purity: 99.02% (May vary between batches)
• Formula: C₁₄H₁₅F₃N₈OS
• SMILES: Nc1nc(nc2n(C[C@H]3CN(Cc4nccs4)CCO3)nnc12)C(F)(F)F
• Target: PDE
• Solubility: DMSO:80 mg/mL (199.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM)

Bioactivity

• Target IC50:
  PDE8B:0.2 nM|PDE8A:0.7 nM
• In Vitro:
  The PDE8 selective inhibitor PF-04957325 exhibits an IC50 of 0.7 nM for PDE8A and 0.2 nM for PDE8B, while its IC50 for all other PDE isoforms is greater than 1.5 μM . Treatment with PF-04957325 in WT Leydig cells or MA10 cells increases steroid production, but has no effect in PDE8A(-/-)/B(-/-) double knockout cells, indicating the drug's specificity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PF 04957325, PF04957325, PF-04957325, PDE8

Compound Identifiers

PubChem CID

52938379