PF-04620110

SKU: orb1685535

Description

PF-04620110 is a potent and selective DGAT1 inhibitor with an IC50 of 19 nM, demonstrating oral activity. It is a valuable research tool for investigating lipid metabolism and metabolic disorders in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1109276-89-2
• MW: 396.44
• Purity: 99.82% (May vary between batches)
• Formula: C₂₁H₂₄N₄O₄
• SMILES: Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
• Target: Acyltransferase|||Transferase
• Solubility: DMSO:19.8 mg/mL (49.94 mM)

Bioactivity

• Target IC50:
  DGAT-1:19 nM
• In Vivo:
  In Rats, PF-04620110 reduces plasma triglyceride levels t doses of ≥0.1 mg/kg following a lipid challenge. DGAT1 inhibition by PF-04620110 causes an enrichment of polyunsaturated fatty acids within the TG class of lipids in rodents.
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• In Vitro:
  Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DGAT1, Diglyceride acyltransferase, Diacylglycerol acyltransferase, acyl-CoA:cholesterol acyltransferase, Acyltransferase, inhibit, mono- acylglycerol acyltransferase, Inhibitor, PF04620110, PF-04620110, PF 04620110

Compound Identifiers

PubChem CID

46926360