Pestanoid A

SKU: orb3141565

Description

Pestanoid A is a rearranged diterpenoid that functions as an osteoclastogenesis inhibitor with an IC50 of 4.2 μM. It can be isolated from the marine-derived fungus Pestalotiopsis sp. (NBUF145). Pestanoid A inhibits NF-kB ligand-induced activation of MAPK and NF-κB signaling pathways by preventing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and the nuclear translocation of NF-κB. This compound may be useful in osteoporosis research.

Research Area

Signal Transduction

Key Properties

• Formula: C₂₀H₂₆O₆
• Target: p38 MAPK,JNK,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK,JNK,ERK