PeS-9

SKU: orb3135315

Description

PeS-9 is an androgen receptor (AR) degrader that induces the degradation of androgen receptors. It enhances the production of cytotoxic reactive oxygen species (ROS), leading to mitochondrial and endoplasmic reticulum stress, which results in the release of mitochondrial cytochrome C and AIF. PeS-9 activates caspase-9 and caspase-3, causing DNA fragmentation and apoptosis. It exhibits anti-prostate cancer activity and demonstrates antitumor and antimetastatic effects in vivo with minimal side effects. PeS-9 is applicable for targeted therapy research in GLUT-1 overexpressing tumors.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Key Properties

• Target: ROS,transporter,p38 MAPK,Apoptosis,Cytochromes P450,Caspase,Calcium Channel,Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROS,transporter,p38 MAPK,Apoptosis,Cytochromes P450,Caspase,Calcium Channel,Mitochondrial Metabolism