Periplocin

SKU: orb1222760

Description

Periplocin has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.

Key Properties

• CAS Number: 13137-64-9
• MW: 696.83
• Purity: >98% (HPLC)
• Formula: C₃₆H₅₆O₁₃
• SMILES: CC1C(C(CC(O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3(C2)O)O)C6=CC(=O)OC6)C)C)OC)OC7C(C(C(C(O7)CO)O)O)O
• Target: HSP
• Solubility: In Vitro: DMSO : 100 mg/mL (143.51 mM)

Bioactivity

• In Vivo:
  Animal model: Female SCID mice (6-8 weeks old) injected with Huh-7 cells. Dosage: 5 mg/kg, 20 mg/kg. Administration: Intraperitoneal injection; daily; for 14 days. Result: Repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.
• In Vitro:
  Cell Viability Assay Cell line: L929 cells. Concentration: 5 μM, 10 μM, 20 μM. Incubation time: 48 hours. Result: Showed increased proliferation up to 131% at 20 μM. Western blot analysis. Cell line: L929 cells. Concentration: 5 μM, 10 μM, 20 μM. Incubation time: 30 minutes, 60 minutes, 120 minutes. Result: Increased phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HSP