Peretinoin

SKU: orb1296232

Description

Peretinoin (NIK333) is an orally available acyclic retinoid analog that acts as a ligand for retinoid X receptors (RXR) and retinoic acid receptors (RAR). It has been investigated in preclinical in vitro and in vivo studies for potential applications in oncology and chemoprevention research.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 81485-25-8
• MW: 302.45
• Purity: 99.86% (May vary between batches)
• Formula: C₂₀H₃₀O₂
• SMILES: CC(C)=CCC\C(C)=C\CC\C(C)=C\C=C\C(\C)=C\C(O)=O
• Target: Retinoid Receptor,HCV Protease,S1P Receptor,Autophagy
• Solubility: DMSO:45 mg/mL (148.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM)

Bioactivity

• In Vitro:
  Peretinoin (10-40 μM; 12-72 hours) exhibits suppressed SPHK1 expression after 24 h treatment, even at 10 μM and more prominent after 72 h peretinoin treatment . Peretinoin (5 μM; 24 hours) up-regulates the expression of LC3B-II and increases autophagy flux in mouse primary hepatocytes . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with an EC50 of 9 μM .
• Cell Research:
  Cell Line: Mouse primary hepatocytes (MPH) and the human HCC HepG2 cell line. Concentration: 5 μM. Incubation Time: 24 hours

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Hepatitis C virus, HCVProtease, HCV Protease, HCV, Inhibitor, NIK 333, NIK333, NIK-333, inhibit, RAR/RXR, RAR, Peretinoin, SphK, Sphingosine kinase, S1PReceptor, S1P Receptor, RXR, Retinoic acid receptors, RetinoidReceptor, Retinoid Receptor, Retinoid X receptors

Compound Identifiers

PubChem CID

6437836