Peramivir Trihydrate

SKU: orb1305362

Description

Peramivir Trihydrate

Research Area

Infectious Disease & Virology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1041434-82-5
• MW: 382.45
• Purity: 99.60%
• Formula: C₁₅H₂₈N₄O₄·3H₂O
• SMILES: O.O.O.CCC(CC)[C@H](NC(C)=O)[C@@H]1[C@H](O)[C@H](C[C@H]1NC(N)=N)C(O)=O
• Target: Influenza Virus,IκB/IKK,STAT,ERK,p38 MAPK,JNK
• Solubility: H2O:6.6 mg/mL (17.26 mM)

Bioactivity

• Target IC50:
  Neuraminidase:0.09 nM
• In Vitro:
  When used in conjunction with favipiravir (20-40 mg/kg/day), peramivir (0.025-0.1 mg/kg/day) increases cell survival rates by 10-50%. At a dosage of 0.5 mg/kg/day, peramivir exhibits a protective effect against H1N1 in mice, covering about 30% of the virus. The combination of peramivir (1 mg/kg/day) with amantadine (5-10 mg/kg/day) results in weight losses of 1.69 and 0.69, respectively; however, for a sub-lethal influenza A (H3N2) virus model in mice, administering peramivir (3 mg/kg/day) alongside rimantadine (10-30 mg/kg/day) does not affect weight. At a higher concentration, peramivir (30 mg/kg) effectively extends the survival of mice infected with the systemically replicating H5N1 virus.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S021812, S-021812, S 021812, RWJ270201, RWJ-270201, RWJ270201 Trihydrate, RWJ-270201 Trihydrate, RWJ 270201, RWJ 270201 Trihydrate, RWJ 270201 trihydrate, Peramivir, Peramivir Trihydrate, BCX 1812, BCX 1812 Trihydrate, BCX 1812 trihydrate, BCX1812, BCX-1812, BCX1812 Trihydrate, BCX-1812 Trihydrate, Inhibitor, inhibit, influenza viral neuraminidase, Influenza Virus, InfluenzaVirus

Compound Identifiers

PubChem CID

11954371