Pemetrexed disodium heptahydrate

SKU: orb3027182

Description

Pemetrexed disodium heptahydrate is a multi-target antifolate agent that potently inhibits thymidylate synthase, dihydrofolate reductase, and GARFT, disrupting nucleotide synthesis. Its application in research includes in vitro and in vivo studies for cancers such as non-small cell lung cancer and malignant pleural mesothelioma.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 357166-29-1
• MW: 597.49
• Purity: 99.78%
• Formula: C₂₀H₃₃N₅Na₂O₁₃
• SMILES: O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1
• Target: DNA/RNA Synthesis,Antifolate,DHFR,Autophagy
• Solubility: H2O:80 mg/mL (133.89 mM)

Bioactivity

• Target IC50:
  GARFT:65 nM (Ki)|DHFR:7.2 nM (Ki)|TS:1.3 nM (Ki)
• In Vivo:
  The survival analysis results showed tha the survival time of mice treated with Pemetrexed disodium heptahydrate combined with Pemetrexed was significantly longer than that of mice treated with Pemetrexed disodium heptahydrate alone, rat IgG combined with Pemetrexed, or those receiving no treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA/RNA Synthesis,Antifolate,DHFR,Autophagy