Peimisine

SKU: orb1222551

Description

Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. Peimisine can attenuate lung tissue injury( ALI), LDH and MDA amount in ALI mice in a dose dependent manner, it also lower the total protein, total white blood cells, lymphocyte and neutrophilic leukocyte in bronchoalveolar lavage fluid( BALF); suggests that peimisine can play a protective role against LPS-induced acute lung injury. Peimisine has the protective effect on the experimental hepatic fibrosis formation, the possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation, and decreasing lipid peroxidation. Peimisine can inhibit angiotensin I converting enzyme activity in a dose-dependent manner, displaying 5 % inhibitory concentration values of 526.5 microM, thus, it may have antihypertensive action.

Key Properties

• CAS Number: 19773-24-1
• MW: 427.62
• Purity: >98% (HPLC)
• Formula: C₂₇H₄₁NO₃
• SMILES: CC1CC2C(C(C3(O2)CCC4C5CC(=O)C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
• Target: Antibacterial
• Solubility: In Vitro: DMSO : 12.5 mg/mL (29.23 mM)

Bioactivity

• In Vitro:
  Peimisine (17.43-92.07 μg/mL; 72 h) shows significant cytotoxic effects. Peimisine (15 μg/mL; 24, 48 and 72 h) induces G0/G1 phase arrest and rising apoptosis rate. Apoptosis Analysis Cell line: A2780 cells. Concentration: 15 μg/mL. Incubation time: 24, 48 and 72 hours. Result: Induced G0/G1 phase arrest of A2780 cells in a time-dependent manner. Cell Cytotoxicity Assay Cell line: LLC, A2780, HepG2 and A549 cells. Concentration: 17.43-92.07 μg/mL Incubation time: 72 hours. Result: Inhibited LLC, A2780, HepG2 and A549 cells with the IC50 values of 20.75 μg/mL, 17.43 μg/mL, 92.07 μg/mL, 36.11 μg/mL, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ebeiensine

Quick Database Links

Gene Symbol

Antibacterial