Pegamotecan

SKU: orb1702960

Description

Pegamotecan is a polyethylene glycol-conjugated camptothecin derivative that acts as a topoisomerase I inhibitor. It has demonstrated anticancer activity in preclinical in vitro and in vivo studies, supporting its research for treating solid tumors such as esophageal, non-small cell lung, and pancreatic cancers.

Research Area

Molecular Biology

Key Properties

• CAS Number: 581079-18-7
• MW: 980.984
• Purity: 97.96% (May vary between batches)
• Formula: C₅₂H₄₈N₆O₁₄
• SMILES: CC[C@@]1(OC(=O)[C@H](C)NC(=O)COCCOCC(=O)N[C@@H](C)C(=O)O[C@]2(CC)C(=O)OCc3c2cc2-c4nc5ccccc5cc4Cn2c3=O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O
• Target: Topoisomerase
• Solubility: DMSO:16.67 mg/mL (16.99 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PEG-camptothecin, PEG-b-CPT, PEG-beta-CPT, Pegamotecan, PEG-β-CPT, topoisomerase I, Prothecan

Compound Identifiers

PubChem CID

11297617