PEG3-O-CH2COOH

SKU: orb1307301

Description

PEG3-O-CH2COOH (PROTAC Linker 8) is a polyethylene glycol-based linker used in constructing PROTACs and SNIPERs. These bifunctional molecules facilitate targeted protein degradation, a strategy widely applied in cancer research and drug discovery for both in vitro and in vivo experimental studies.

Research Area

Cell Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 51951-05-4
• MW: 208.209
• Purity: 99.90% (May vary between batches)
• Formula: C₈H₁₆O₆
• SMILES: O=C(O)COCCOCCOCCO
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PEG3-O-CH2COOH (Compound 15b) is a PROTAC linker utilized in synthesizing SNIPER(ER)s, which recruit inhibitors of the apoptosis protein (IAP) ubiquitin ligases to selectively degrade targeted proteins.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, PEG3OCH2COOH, PEG-3-O-CH2COOH, PEG3-O-CH2COOH, PEG3 O CH2COOH, inhibit, PEGs, PROTAC Linker, PROTAC Linker 8, PROTAC Linker8, PROTAC Linker-8, PROTAC Linkers, PROTACLinker

Compound Identifiers

PubChem CID

12679071