Pefloxacin

SKU: orb1941019

Description

Pefloxacin is a an antibacterial agent and prevents bacterial Dna replication by inhibiting Dna gyrase (topoisomerse) Target: Dna gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States. The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes Dna gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial Dna. Dna gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result Dna replication and transcription is inhibited.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 70458-92-3
• MW: 333.36
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₀FN₃O₃
• SMILES: O=C(C1=CN(CC)C2=C(C=C(F)C(N3CCN(C)CC3)=C2)C1=O)O
• Target: Antibacterial

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pefloxacin | 1584RB | 1589 RB | EU 5306 EU-5306 | Pefloxacinium

Quick Database Links

Gene Symbol

Antibacterial