PDGFRα kinase-IN-2

SKU: orb3136849

Description

PDGFRαkinase-IN-2 is a potent inhibitor of PDGFR-α with an IC50 of 2.1 nM. It exhibits anticancer activity against human colon cancer HT-29 cells, with an IC50 of 1.48 μM. Additionally, PDGFRαkinase-IN-2 demonstrates anti-angiogenic properties in zebrafish models with low embryotoxicity, making it suitable for research in colon cancer and anti-angiogenesis.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 3066103-58-7
• MW: 429.47
• Formula: C₂₄H₂₃N₅O₃
• SMILES: O=C(NC1=CC=C(C=C1)NC=2N=CN=C3C=C(OC)C(OC)=CC32)NC4=CC=CC(=C4)C
• Target: PDGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDGFR