PDE/TRPA1/CHIT1-IN-1

SKU: orb3174643

Description

PDE/TRPA1/CHIT1-IN-1 is an inhibitor of PDEs, TRPA1, and hCHIT1 with a KD value of 37.7 μM. It acts as a broad-spectrum PDE inhibitor, effectively targeting key subtypes including PDE4B, PDE7A, PDE3A, and PDE8A with IC50 values of 15.54, 15.15, 8.39, and 16.46 μM, respectively. By inhibiting NLRP3 inflammasome activation and blocking NF-κB phosphorylation, PDE/TRPA1/CHIT1-IN-1 downregulates the expression of pro-inflammatory genes (TNF-α and IL-6) in vivo. This compound is useful for research into chronic obstructive pulmonary disease (COPD) and related inflammatory lung conditions.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: PDE,Interleukin,TNF,TRP/TRPV Channel,NOD-like Receptor (NLR),NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE,Interleukin,TNF,TRP/TRPV Channel,NOD-like Receptor (NLR),NF-κB