PDEδ/NAMPT IN-1

SKU: orb3027604

Description

PDEδ/NAMPT IN-1 (Compound 17d) is a dual inhibitor targeting phosphodiesterase 6 (PDE6) with a dissociation constant (KD) of 0.410 nM and nicotinamide phosphoribosyltransferase (NAMPT) with an inhibitory concentration (IC50) of 2.21 nM. It disrupts KRAS-related signaling by inhibiting NAMPT's role in the synthesis of nicotinamide adenine dinucleotide (NAD+), consequently inducing apoptosis in pancreatic cancer cells with KRAS mutations. This compound holds potential for research in KRAS-mutant pancreatic cancer.

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2976498-55-0
• MW: 494.61
• Formula: C₂₆H₃₀N₄O₄S
• SMILES: O=C(NC1=CC=C(C=C1)S(=O)(=O)N(CC2=CC=C(OC)C=C2)C3CCCC3)NCC=4C=NC=CC4
• Target: Kras,Ras,NAMPT,Apoptosis,PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Kras,Ras,NAMPT,Apoptosis,PDE