PDE9-IN-(S)-C33

SKU: orb1304959

Description

(S)-C33 is a potent and selective PDE9 inhibitor (IC50 = 11 nM). It is a valuable research tool for investigating the role of PDE9 in central nervous system disorders and diabetes, with utility in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2066488-39-7
• MW: 357.84
• Purity: 99.53% (May vary between batches)
• Formula: C₁₈H₂₀ClN₅O
• SMILES: O=C1C2=C(N(N=C2)C3CCCC3)NC(N[C@@H](C)C4=CC=C(Cl)C=C4)=N1
• Target: PDE
• Solubility: DMSO:95 mg/mL (265.48 mM)

Bioactivity

• Target IC50:
  PDE5A1:366 ± 38 nM|PDE9A:11 ± 4 nM|PDE2A:2.4 ± 0.5 μM|PDE4D2:1.3 ± 0.1 μM|PDE10A1:2.3 ± 0.3 μM|PDE1B:554 ± 64 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE5A1, PDE4D2, PDE9-IN-C33, PDE9 IN (S) C33, PDE9A, PDE9IN(S)C33, PDE1B, PDE10A1, PDE2A, C 33, C33, C-33, Central nervous system diseases, Selectivity

Compound Identifiers

PubChem CID

135567003