PDE4-IN-29

SKU: orb3135547

Description

PDE4-IN-29 (Compound 55) is an orally active and selective inhibitor of PDE4, targeting subtypes such as PDE4A1, PDE4B2, and PDE4D3, with an IC50 value for PDE4D3 of less than 5 nM. It inhibits the degradation of cyclic adenosine monophosphate (cAMP), elevating intracellular cAMP levels and suppressing the release of inflammatory mediators like TNF-α. PDE4-IN-29 holds potential for research in inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2815361-45-4
• MW: 546.63
• Formula: C₂₇H₃₄N₂O₈S
• SMILES: O=C1C=2C(C(=O)N1[C@H](CS(C)(=O)=O)C3=CC(OCC)=C(OC)C=C3)=C(NC(C)=O)C=CC2C(CCCC)O
• Target: PDE

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE