PDE3/4-IN-4

SKU: orb3210547

Description

PDE3/4-IN-4 is an orally active inhibitor targeting both PDE3A and PDE4B with an IC50 of 10 nM for PDE3A and 9.4 nM for PDE4B, demonstrating selective activity compared to most other PDE family members. It modulates the cAMP/PKA/CREB signaling pathway, inhibits the pro-inflammatory factor IL-6, and reduces the expression of inflammatory markers in liver tissue. PDE3/4-IN-4 alleviates liver fibrosis and limits liver injury in mouse models of cholestasis and sepsis-induced liver damage. This compound is applicable in studies related to liver injury, cholestatic liver disease, and sepsis-induced liver damage.

Key Properties

• CAS Number: 3088024-27-2
• MW: 559.56
• Formula: C₃₀H₂₇F₂N₅O₄
• SMILES: O=C(NC=1C=CC(=CC1)C2=NNC(=O)CC2C)C=3C=CC=C4N=C(NC43)C=5C=CC(OC(F)F)=C(OCC6CC6)C5
• Target: PDE,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE,Interleukin