PDE1-IN-5

SKU: orb2277983

Description

PDE1-IN-5 (Compound 10c) is a potent and selective PDE1C inhibitor (IC50 = 15 nM) with demonstrated anti-inflammatory activity. It suppresses LPS-induced pro-inflammatory mediators like iNOS, TNF-α, and interleukins. Its efficacy in reducing colitis symptoms in a DSS-induced mouse model highlights its utility for inflammatory disease research, particularly for studying IBD mechanisms.

Research Area

Metabolism Research

Key Properties

• MW: 444.54
• Formula: C₂₇H₂₉FN₄O
• Target: PDE,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE,Others