PDE1-IN-5

SKU: orb2277983

Description

PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 expression induced by LPS. It has demonstrated efficacy in mitigating inflammatory bowel disease (IBD) symptoms in a dextran sodium sulfate (DSS)-induced colitis mouse model, suggesting its potential utility for IBD research.

Key Properties

• MW: 444.54
• Formula: C₂₇H₂₉FN₄O
• Target: Others,PDE

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others,PDE