PD173952

SKU: orb1702967

Description

PD173952 is a small molecule inhibitor targeting Src family kinases (including Lyn), Abl, Csk, and Myt1. It induces apoptosis in Bcr-Abl-dependent hematopoietic cells and has demonstrated antitumor activity in research studies, making it a tool for investigating leukemia and related cancers in vitro.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 305820-75-1
• MW: 482.36
• Purity: 99.50% (May vary between batches)
• Formula: C₂₄H₂₁Cl₂N₅O₂
• SMILES: O=C1C(=CC=2C=NC(=NC2N1C)NC3=CC=C(C=C3)N4CCOCC4)C5=C(Cl)C=CC=C5Cl
• Target: Src,Bcr-Abl,Apoptosis,Wee1
• Solubility: DMSO:15 mg/mL (31.1 mM)

Bioactivity

• Target IC50:
  Abl:1.7 nM|Csk:6.6 nM|Lyn:0.3 nM|Myt1:8.1 nM (Ki)
• In Vitro:
  METHODS: K562 cells were treated with PD173952 (0.05-1μM, 12 hours), and the protein expression levels of p210Bcr-Abl or CrkL were detected by Western Blot. RESULTS:PD173952 could inhibit the tyrosine phosphorylation of p210 (Bcr-Abl antibody) and CrkL in K562 cells in a concentration-dependent manner.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Myt1, PD173952, PD-173952, PD 173952, Src

Compound Identifiers

PubChem CID

5328733