PD153035

SKU: orb1306664

Description

PD153035 hydrochloride is a potent and highly selective EGFR inhibitor with a Ki of 5.2 pM. It exhibits minimal activity against FGFR, PDGFR, InsR, CSF-1R, and Src. This compound is widely used in cancer research to study EGFR-driven signaling pathways in both cellular and animal models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 153436-54-5
• MW: 360.21
• Purity: 99.31% (May vary between batches)
• Formula: C₁₆H₁₄BrN₃O₂
• SMILES: COC1=CC2=NC=NC(NC3=CC(Br)=CC=C3)=C2C=C1OC
• Target: EGFR
• Solubility: DMSO:5 mg/mL (13.88 mM)

Bioactivity

• Target IC50:
  EGFR:29 pM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG 1517, AG1517, AG-1517, inhibit, Inhibitor, NSC 669364, NSC669364, NSC-669364, PD153035, PD-153035, PD 153035, Epidermal growth factor receptor, ErbB-1, EGFR, HER1, SU5271, SU-5271, SU 5271, ZM-252868, ZM252868, ZM 252868

Compound Identifiers

PubChem CID

4705