PD-150606

SKU: orb1985180

Description

PD150606 is a selective, nonpeptide neuroprotective agent that functions as a calpain inhibitor, targeting both μ- and m-calpain isoforms. It has demonstrated efficacy in reducing calcium dysregulation and excitotoxic motor neuron death in vitro, showing potential for research in neurodegenerative disease models such as amyotrophic lateral sclerosis (ALS) and ischemic injury.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 179528-45-1
• MW: 306.12
• Purity: >98%
• Formula: C₉H₇IO₂S
• SMILES: OC(=O)C(\S)=C\c1ccc(I)cc1
• Target: Protease
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml).

Bioactivity

• Target IC50:
  m-Calpain:0.37 μM (Ki)|μ-Calpain:0.21 μM (Ki)
• In Vitro:
  PD 150606 (25 μM; 0-12 hours) can partially reduce apoptosis of neutrophils induced by staurosporine.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Compound T3525, Compound T-3525, Compound T 3525, CysteineProtease, Cysteine Protease, calpain

Compound Identifiers

PubChem CID

9839500