PD-M6

SKU: orb3027776

Description

PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC50 values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3058330-82-5
• MW: 621.69
• Formula: C₃₀H₃₉N₉O₆
• SMILES: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCNC=4N=C(N=C(N4)N5CCOCC5)N6CCOCC6)C3C2=O)CC1
• Target: PROTACs,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,mTOR