PD-L1/Nampt-IN-1

SKU: orb3136654

Description

PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 3054043-85-2
• MW: 452.55
• Formula: C₂₈H₂₈N₄O₂
• SMILES: O=C(NCCNCC=1C=CC(=NC1OC)C=2C=CC=C(C=3C=CC=CC3)C2C)C=4C=NC=CC4
• Target: NAMPT,PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NAMPT,PD-1/PD-L1