PD-L1/HDAC-IN-1

SKU: orb2944949

Description

PD-L1/HDAC-IN-1 (Compound 14) is a dual inhibitor of the PD-1/PD-L1 axis and HDAC2/3, with IC50 values in the nanomolar range. It upregulates PD-L1 and CXCL10 in vitro, promoting T-cell recruitment to the tumor microenvironment for immune-oncology research in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Immunology & Inflammation; Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2923313-69-1
• MW: 740.284
• Formula: C₄₂H₄₆ClN₃O₇
• SMILES: C(C1=C(OCC2=CC(C#N)=CC=C2)C=C(OCC3=C(C)C(=CC=C3)C4=CC(OCCCCCCC(NO)=O)=CC=C4)C(Cl)=C1)N5[C@@H](C(O)=O)CCCC5
• Target: PD-1/PD-L1,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166072580