PD 407824

SKU: orb1706837

Description

PD 407824 is a BMP sensitizer that enhances cellular response to low-dose BMP4. It functions as a potent dual inhibitor of Chk1 and WEE1 kinases (IC50s: 47 and 97 nM). This compound is used in vitro to study DNA damage checkpoint bypass, stem cell differentiation, and cancer cell sensitization in research.

Research Area

Cell Biology

Key Properties

• CAS Number: 622864-54-4
• MW: 328.32
• Purity: 98.02% (May vary between batches)
• Formula: C₂₀H₁₂N₂O₃
• SMILES: Oc1ccc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1ccccc1
• Target: Chk,Wee1
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (12.18 mM);DMSO:100 mg/mL (304.58 mM)

Bioactivity

• Target IC50:
  Chk1:47 nM|WEE1:97 nM
• In Vitro:
  Inhibiting Wee1 and Chk1 kinases can lead to the disappearance of DNA damage-induced G2 checkpoint. Research findings indicate that PD 407824 selectively acts on CHK1 and WEE1, with IC50 values exceeding 3.4µM and 3.75µM for PKC and Cdk4, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chk1, PD 407824, PD407824, PD-407824, Wee1, WEE1

Compound Identifiers

PubChem CID

4369491